Chronic lymphocytic leukemia presenting with ascites diagnosed by clonality analysis via gene rearrangement assay: A case report
| Autor: | Tung‑Liang Lin, Jin‑Hou Wu, Yen Min Huang, Po‑Nan Wang, Yu‑Shin Hung, Lee‑Yung Shih, Tzung‑Chih Tang, Hsiao‑Wen Kao, Po Dunn, Ming‑Chung Kuo, Hsuan‑Jen Shih, Hung Chang |
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| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Chronic lymphocytic leukemia gene rearrangement ascites immune system diseases hemic and lymphatic diseases Ascites Biopsy Medicine neoplasms biology Oncogene medicine.diagnostic_test business.industry Articles Gene rearrangement medicine.disease medicine.anatomical_structure Oncology Pleomorphism (cytology) biology.protein chronic lymphocytic leukemia Bone marrow Antibody medicine.symptom business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2014.2044 |
| Popis: | The diagnosis of chronic lymphocytic leukemia (CLL) presenting with ascites is predominantly based on the morphological and immunophenotypic characteristics, which are comparable to peripheral blood and bone marrow cells. However, it is relatively difficult to diagnose CLL due to the pleomorphism of the lymphocytes in ascites. The current study presents an 80-year-old male with a prior diagnosis of CLL who developed large ascites. Predominant T lymphocytes rendered morphological and immunophenotypic diagnosis difficult. Clonality analysis of immunoglobulin (Ig) gene rearrangements was performed on the lymphocytes from the ascites to diagnose the involvement of CLL, a laparotomy and biopsy from the peritoneal node confirmed the involvement of small lymphocytic lymphoma/CLL. The clonality analysis of Ig gene rearrangements may provide a powerful and accurate method for diagnosing CLL presenting with ascites. |
| Databáze: | OpenAIRE |
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