Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study
| Autor: | Marek Brabec, Marisa A. Nunes, Juraj Michalec, Jana Urbanová, Arian Taniwall, Matthew Campbell, Jan Brož, Ludmila Brunerová, Vojtěch Berka, Jan Polak, Denisa Janíčková Žďárská, Dario Rahelić |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose Male type 1 diabetes Administration Oral Pilot Projects Hypoglycemia Target heart rate Article Heart Rate medicine Humans Insulin TX341-641 Glucose dynamics glycemic excursion Glycemic Type 1 diabetes hypoglycemia treatment Nutrition and Dietetics exercise business.industry Nutrition. Foods and food supply medicine.disease hypoglycemia insulin therapy Bicycling Oral ingestion Diabetes Mellitus Type 1 Glucose Male patient Anesthesia Heart rate reserve business Food Science |
| Zdroj: | Nutrients Nutrients; Volume 13; Issue 11; Pages: 4165 Nutrients, Vol 13, Iss 4165, p 4165 (2021) |
| ISSN: | 2072-6643 |
| Popis: | The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min−1 (minimum: 0.07, maximum: 0.17 mmol/L·min−1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min−1 (minimum: 0.06, maximum: 0.19 mmol/L·min−1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window. |
| Databáze: | OpenAIRE |
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