Effects of Ipragliflozin on Diabetic Nephropathy and Blood Pressure in Patients With Type 2 Diabetes: An Open-Label Study
| Autor: | Mitsuhiko Noda, Kazuyuki Inoue, Emi Ikuma-Suwa, Morifumi Yanagisawa, Kouichi Inukai, Daisuke Ito, Akira Shimada, Kimie Kaneko |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Urinary system Urology Renal function 030209 endocrinology & metabolism Diabetic nephropathy Type 2 diabetes 030204 cardiovascular system & hematology Sodium-glucose cotransporter 2 inhibitor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine business.industry General Medicine medicine.disease Ipragliflozin Endocrinology Blood pressure chemistry Original Article Glycated hemoglobin business Glomerular hyperfiltration |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| DOI: | 10.14740/jocmr2875w |
| Popis: | Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are novel agents used to treat type 2 diabetic patients. We investigated the efficacy of the SGLT2 inhibitor ipragliflozin on diabetic nephropathy in Japanese patients with type 2 diabetes. Methods: A 50 mg dose of ipragliflozin was administered for 24 weeks to 50 patients with type 2 diabetes who were concomitantly managed with diet and exercise therapy alone or antidiabetic medications other than SGLT2 inhibitors. Results: At the end of the 24-week ipragliflozin treatment, significant decreases in mean glycated hemoglobin (HbA1c) (1.0±1.2%) and body weight (2.7 ± 2.5 kg) were observed; in addition, median urinary albumin-to-creatinine ratio (UACR) significantly decreased from 15.5 (8.0 - 85.7) to 12.9 (7.4 - 36.3) mg/gCr. Sub-analysis by renal function at baseline revealed that median UACR in patients with estimated glomerular filtration rate (eGFR) ≥ 90 mL/min/1.73 m 2 decreased significantly from 12.3 (7.5 - 89.6) to 10.6 (5.8 - 27.3) mg/gCr. Furthermore, mean eGFR decreased significantly from 102.4 ± 8.6 to 93.6 ± 10.5 mL/min/1.73 m 2 in these patients. In contrast, UACR and eGFR did not change significantly in patients with eGFR < 90. In addition, analysis of the relationship between the amount of change in UACR and blood pressure at 24 weeks revealed a significant positive correlation between UACR and SBP values, independently of the presence of diabetic nephropathy. Conclusions: Our results indicate that ipragliflozin may facilitate HbA1c control and body weight reduction. Furthermore, our results also raise the possibility that ipragliflozin significantly reduces urinary albumin levels and improves glomerular hyperfiltration in a subset of patients with type 2 diabetes. J Clin Med Res. 2017;9(2):154-162 doi: https://doi.org/10.14740/jocmr2875w |
| Databáze: | OpenAIRE |
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