Pulmonary Macrophage Cell Death in Lung Health and Disease
| Autor: | Abigail M. Shotland, Amy S. McKee, Andrew P. Fontenot |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Necrosis Clinical Biochemistry Apoptosis Disease Adaptive Immunity 03 medical and health sciences 0302 clinical medicine Accidental cell death Macrophages Alveolar Pyroptosis Medicine Alarmins Animals Humans Molecular Biology Lung Respiratory Distress Syndrome Innate immune system business.industry Translational Reviews Macrophage cell Epithelial Cells Cell Biology Lung Injury respiratory system Acquired immune system Immunity Innate 030104 developmental biology 030228 respiratory system Gene Expression Regulation Lung health Immunology Cytokines medicine.symptom business Apoptosis Regulatory Proteins human activities Signal Transduction |
| Zdroj: | Am J Respir Cell Mol Biol |
| ISSN: | 1535-4989 |
| Popis: | Over the last several decades, our understanding of regulated-cell-death (RCD) pathways has increased dramatically. In addition to apoptosis and accidental cell death (primary necrosis), a diverse spectrum of RCD pathways has been delineated. In the lung, airway macrophages are critical for maintaining the functionality of airways via the clearance of inhaled particles, cell debris, and infectious agents. Exposure of these cells to pathogenic organisms or particles can induce a variety of RCD pathways that promote the release of danger signals into the lung. These responses have evolved to trigger the innate and adaptive arms of the immune system and thus offer protection against pathogens; yet they can also contribute to the development of lung injury and pathogenic immune responses. In this review, we discuss recent studies that suggest a critical role for airway-macrophage RCD pathways in promoting the release of pulmonary danger signals in health and disease. |
| Databáze: | OpenAIRE |
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