Relative survival in patients with dementia with Lewy bodies and Parkinson’s disease dementia
| Autor: | Elisabet Londos, Gustav Torisson, Victoria Larsson |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Pervasive Developmental Disorders Parkinson's disease Apolipoprotein E4 Dementia with Lewy bodies Social Sciences lcsh:Medicine Alzheimer's Disease Cognition Learning and Memory 0302 clinical medicine Psychology Mental health and psychiatry 030212 general & internal medicine lcsh:Science Aged 80 and over education.field_of_study Movement Disorders Multidisciplinary Relative survival Mortality rate Hazard ratio Parkinson Disease Neurodegenerative Diseases Neurology Population Surveillance Alzheimer's Disease Diagnosis and Management Female Research Article Lewy Body Disease medicine.medical_specialty Death Rates Population 03 medical and health sciences Population Metrics Diagnostic Medicine Memory Internal medicine mental disorders medicine Humans Dementia education Aged Proportional Hazards Models Retrospective Studies Sweden Medicine and health sciences Population Biology business.industry lcsh:R Biology and Life Sciences medicine.disease Standardized mortality ratio Developmental Psychology Cognitive Science lcsh:Q business 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, Vol 13, Iss 8, p e0202044 (2018) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0202044 |
| Popis: | Introduction The understanding of survival in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) is limited, as well as the impact of these diagnoses in an ageing co-morbid population. Methods A retrospective study of 177 patients who received a DLB or PDD diagnosis between 1997–2014 at the Memory Clinic in Malmo, Sweden. Relative survival was evaluated by adjusting all-cause survival for expected survival, estimated from population life-tables, matched by sex, age and calendar year. Predictors of relative survival were investigated using multivariate regression modelling. Results At follow-up, 143 (81%) patients were deceased with a median survival of 4.1 years (IQR 2.6–6.0). After 10-years follow-up, the standardized mortality ratio was 3.44 (95% CI 2.92–4.04). Relative survival was worse with younger age at diagnosis (excess hazard ratio [eHR] 0.91, 95% CI 0.88–0.94 per year of age), female sex (eHR 1.45, 95% CI 1.01–2.09) and lower mini-mental state examination (eHR 0.93, 95% CI 0.90–0.96). Subgroup analysis (n = 141) showed higher mortality in DLB patients who were positive for APOE ɛ4 (eHR 2.00, 95% CI 1.35–2.97). Conclusion The mortality is over three-times higher in patients diagnosed with dementia with Lewy bodies and Parkinson’s disease dementia during a ten-year follow-up, compared to persons in the general population. Excess mortality is found primarily in younger patients, females and carriers of APOE e4. Further research is needed regarding survival and possible interventions, including disease-modifying treatments, to improve care for this patient group. |
| Databáze: | OpenAIRE |
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