RETRACTED: Pulmonary route of administration is instrumental in developing therapeutic interventions against respiratory diseases
| Autor: | Shui Yu, Jin Xue, Yan-Chun Zhang, Chao-Chao Ma, Ling Song |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
Sustained delivery medicine.medical_specialty media_common.quotation_subject Psychological intervention Pharmaceutical Science Pulmonary disease Diseases Review 02 engineering and technology 030226 pharmacology & pharmacy 03 medical and health sciences Pulmonary Absorption Route of administration 0302 clinical medicine medicine Intensive care medicine media_common Pharmacology business.industry lcsh:RM1-950 Polymerosomes Pulmonary 021001 nanoscience & nanotechnology Important research lcsh:Therapeutics. Pharmacology Semi fluorinated alkanes Drug delivery Nanoparticles 0210 nano-technology business |
| Zdroj: | Saudi Pharmaceutical Journal : SPJ Saudi Pharmaceutical Journal, Vol 28, Iss 12, Pp 1655-1665 (2020) |
| ISSN: | 1319-0164 |
| Popis: | Pulmonary route of drug delivery has drawn significant attention due to the limitations associated with conventional routes and available treatment options. Drugs administered through pulmonary route has been an important research area that focuses on to developing effective therapeutic interventions for asthma, chronic obstructive pulmonary disease, tuberculosis, lung cancer etc. The intravenous route has been a natural route of delivery of proteins and peptides but associated with several issues including high cost, needle-phobia, pain, sterility issues etc. These issues might be addressed by the pulmonary administration of macromolecules to achieving an effective delivery and efficacious therapeutic impact. Efforts have been made to develop novel drug delivery systems (NDDS) such as nanoparticles, microparticles, liposomes and their engineered versions, polymerosomes, micelles etc to achieving targeted and sustained delivery of drug(s) through pulmonary route. Further, novel approaches such as polymer-drug conjugates, mucoadhesive particles and mucus penetrating particles have attracted significant attention due to their unique features for an effective delivery of drugs. Also, use of semi flourinated alkanes is in use for improvising the pulmonary delivery of lipophilic drugs. Present review focuses on to unravel the mechanism of pulmonary absorption of drugs for major pulmonary diseases. It summarizes the development of interventional approaches using various particulate and vesicular drug delivery systems. In essence, the orchestrated attempt presents an inflammatory narrative on the advancements in the field of pulmonary drug delivery. |
| Databáze: | OpenAIRE |
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