Development of Water Solubility of 2-Phenylsulfanylhydroquinone Dimer Dye

Autor:	Takeshi Honda, Haruka Umemoto, Takuji Kawamoto, Akio Kamimura
Rok vydání:	2021
Předmět:	Aqueous solution biology General Chemical Engineering Bioactive molecules Dimer Light irradiation General Chemistry Combinatorial chemistry Fluorescence Article Chemistry chemistry.chemical_compound chemistry biology.protein Side chain Molecule Bovine serum albumin QD1-999
Zdroj:	ACS Omega ACS Omega, Vol 6, Iss 13, Pp 9254-9262 (2021)
ISSN:	2470-1343
DOI:	10.1021/acsomega.1c00703
Popis:	With the aim of developing a new fluorescence dye with enhanced photophysical properties, this study describes the modification of the 2-phenylsulfanylhydroquinone dimer to realize a new bioimaging molecule. The characteristics of the dimer were advanced by introducing tetraethylene glycol side chains to provide sufficient water solubility and a tether consisting of an N-hydroxysuccinimide-terminated C6-carbon chain to attach bioactive molecules. Two derivatives containing two or three tetraethylene glycol side chains were designed and prepared, and the latter showed sufficient water solubility for biochemical applications. Both compounds exhibited similar photophysical properties and blue fluorescence under UV light irradiation. The dye containing three tetraethylene glycol units reacted with bovine serum albumin in water to give fluorescent derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885fc14406e3518a955b44a6863441ab https://doi.org/10.1021/acsomega.1c00703 Zobrazit plný text záznamu