Multifaceted Aspects of Metabolic Plasticity in Human Cholangiocarcinoma: An Overview of Current Perspectives
| Autor: | Mirella Pastore, Pietro Invernizzi, Giulia Lori, Di Maira G, Claudia Campani, A. Gentilini, Fabio Marra, Chiara Raggi, Stefania Recalcati, Maria Letizia Taddei |
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| Přispěvatelé: | Pastore, M, Lori, G, Gentilini, A, Taddei, M, Di Maira, G, Campani, C, Recalcati, S, Invernizzi, P, Marra, F, Raggi, C |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Bioenergetics Cell Plasticity Druggability PGC-1α Computational biology Review Biology Mitochondrion fatty acids Metastasis 03 medical and health sciences 0302 clinical medicine MED/12 - GASTROENTEROLOGIA OXPHOS cholangiocarcinoma fatty acid synthase mitochondria tricarboxylic acid cycle medicine Humans lcsh:QH301-705.5 Cell Proliferation General Medicine medicine.disease Warburg effect 030104 developmental biology Bile Duct Neoplasms lcsh:Biology (General) 030220 oncology & carcinogenesis Cancer cell fatty acid Signal transduction Reprogramming |
| Zdroj: | Cells, Vol 9, Iss 3, p 596 (2020) Cells |
| Popis: | Cholangiocarcinoma (CCA) is a deadly tumor without an effective therapy. Unique metabolic and bioenergetics features are important hallmarks of tumor cells. Metabolic plasticity allows cancer cells to survive in poor nutrient environments and maximize cell growth by sustaining survival, proliferation, and metastasis. In recent years, an increasing number of studies have shown that specific signaling networks contribute to malignant tumor onset by reprogramming metabolic traits. Several evidences demonstrate that numerous metabolic mediators represent key-players of CCA progression by regulating many signaling pathways. Besides the well-known Warburg effect, several other different pathways involving carbohydrates, proteins, lipids, and nucleic acids metabolism are altered in CCA. The goal of this review is to highlight the main metabolic processes involved in the cholangio-carcinogeneis that might be considered as potential novel druggable candidates for this disease. |
| Databáze: | OpenAIRE |
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