Advantages and disadvantages of apoptosis in the aging process
| Autor: | Antonio Ayala, Mercedes Cano, Angélica Guerrero-Castilla, Sandro Argüelles, Mario F. Muñoz |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Senescence Aging business.industry Process (engineering) General Neuroscience Apoptosis Human being General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine History and Philosophy of Science Life expectancy Animals Humans Medicine Healthy aging business Neuroscience 030217 neurology & neurosurgery Organism Signal Transduction |
| Zdroj: | Annals of the New York Academy of Sciences. 1443:20-33 |
| ISSN: | 1749-6632 0077-8923 |
| Popis: | Researchers cannot predict as yet how long a human being can live. Life expectancy has been steadily increasing in the last century, but perhaps not always the quality of life in parallel with it. Future generations will be faced with the problems of an increased life expectancy along with the emergence of new age-related diseases. A deeper understanding of the aging process is crucial to ameliorate, if not to prevent, these projected new old-age diseases. One of the mechanisms responsible for healthy aging is through the effective maintenance of physiological, biochemical, and immunological functions. To carry this out, the organism needs to create new cells to replace old ones and to induce the disappearance of old and damaged cells. Apoptosis is involved in all these processes. However, if apoptosis is dysregulated, premature senescence-associated diseases are likely to appear. In our review, the focus will be on a better understanding of the role of apoptosis in the aging process. These signaling pathways will most assuredly be pharmacologically targeted in antiaging medicine therapies. |
| Databáze: | OpenAIRE |
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