Glycans in villus trophoblast in iron defi ciency anemia and early-onset severe preeclampsia
| Autor: | Beatriz Elena Parra-Sosa, Julio César Bueno-Sánchez, Alejandra María Gómez-Gutiérrez |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Glycosylation Anemia preclámpsia grave Anaemia agrovoc:c_380 Biology Maternal blood Cell membrane Anemia gestacional chemistry.chemical_compound Syncytiotrophoblast Internal medicine medicine Early-onset severe preeclampsia Close contact glicosilación reproductive and urinary physiology chemistry.chemical_classification Nutrition and Dietetics Transferrin-receptor 1 medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure Endocrinology hierro chemistry embryonic structures receptor 1 de transferrina Glycoprotein Food Science |
| Zdroj: | Revista chilena de nutrición v.42 n.2 2015 SciELO Chile CONICYT Chile instacron:CONICYT Repositorio UdeA Universidad de Antioquia instacron:Universidad de Antioquia |
| Popis: | Glycoproteins attached to cell membrane of syncytiotrophoblast are in close contact with maternal blood, thus these molecules could participate in cell-to-cell communication and biological functions involving ligand-receptors in the maternal-fetal interphase. The attached glycans are involved in the stability, folding and exportation of the protein towards the cell membrane. The objective of this study was to characterize the glycan profi le of third trimester placental villi obtained from pregnant women with early-onset severe preeclampsia and gestational anemia compared with normal pregnant women. Protein extracts from placental villi were used in lectin blot assays. -2,3 N- and O-linked sialic acid was over-expressed in villous of severe preeclamptic placentas measured by MAA lectin staining. High mannose glycans and Gal-GlcNAc patterns were also increased in severe preeclampsia compared with the other groups. These findings can explain changes in the cell membrane expression of glycoproteins. COL0000407 COL0007631 |
| Databáze: | OpenAIRE |
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