Pneumococcal Cell Wall-Induced Meningitis Impairs Adult Hippocampal Neurogenesis
| Autor: | Joerg R. Weber, Dorette Freyer, Heidrun Fink, Bettina Bert, Cordula Mahrhofer, Olaf Hoffmann, Nina Rueter |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Aging Immunology Central nervous system Hippocampus Inflammation Hippocampal formation Biology Microbiology Mice Cell Wall medicine Animals Cell Proliferation Neurons Host Response and Inflammation Microglia Meningitis Pneumococcal Dentate gyrus Neurogenesis medicine.disease Infectious Diseases medicine.anatomical_structure nervous system Parasitology medicine.symptom Meningitis |
| Zdroj: | Infection and Immunity. 75:4289-4297 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.01679-06 |
| Popis: | Bacterial meningitis is a major infectious cause of neuronal degeneration in the hippocampus. Neurogenesis, a continuous process in the adult hippocampus, could ameliorate such loss. Yet the high rate of sequelae from meningitis suggests that this repair mechanism is inefficient. Here we used a mouse model of nonreplicative bacterial meningitis to determine the impact of transient intracranial inflammation on adult neurogenesis. Experimental meningitis resulted in a net loss of neurons, diminished volume, and impaired neurogenesis in the dentate gyrus for weeks following recovery from the insult. Inducible nitric oxide synthase (iNOS) immunoreactivity was prominent in microglia in nonproliferating areas of the dentate gyrus and hilus region after meningitis induction. Treatment with the specific iNOS inhibitorN6-(1-iminoethyl)-l-lysine restored neurogenesis in experimental meningitis. These data suggest that local central nervous system inflammation in and of itself suppresses adult neurogenesis by affecting both proliferation and neuronal differentiation. Repair of cognitive dysfunction following meningitis could be improved by intervention to interrupt these actively suppressive effects. |
| Databáze: | OpenAIRE |
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