German Maternal Phenylketonuria Study
| Autor: | S. Cipcic-Schmidt, Kurt Ullrich, G. Seidlitz, F. K. Trefz, B Fünders |
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| Rok vydání: | 1996 |
| Předmět: |
Pediatrics
medicine.medical_specialty Phenylketonuria Maternal Offspring Dietary control Intelligence Growth Child Development Pregnancy Internal medicine Germany medicine Diet Protein-Restricted Humans Maternal phenylketonuria Interim report Amino Acid Metabolism Inborn Errors business.industry Pregnancy Outcome Gestational age Infant medicine.disease Phenylalanine restricted diet Endocrinology Dietary treatment Pediatrics Perinatology and Child Health Female business |
| Zdroj: | European journal of pediatrics. 155 |
| ISSN: | 0340-6199 |
| Popis: | The German maternal phenylketonuria (MPKU) Study began in 1989 and since 1992 works together with the American-Canadian MPKU Study. Main goals of the study are: (1) to find women with phenylketonuria (PKU) and mild untreated hyperphenylalaninaemia (HPA); (2) to inform them about the risks of an untreated pregnancy with PKU and HPA; (3) to evaluate the efficacy of the phenylalanine (Phe) restricted dietary treatment prior to and during pregnancy by following the physical and cognitive development of offspring from treated pregnancies. An interim report of the study is presented. Until now, 43 pregnancies have been followed. They resulted in 34 live births, 24 from women with PKU and 10 from women with HPA. There are significant negative correlations between the gestational age in which the dietary control (blood Phe level |
| Databáze: | OpenAIRE |
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