High levels of butyrate and propionate in early life are associated with protection against atopy

Autor: Anne M. Karvonen, Pirkka V. Kirjavainen, Christophe Chassard, Cezmi A. Akdis, Elisabeth Schmausser-Hechfellner, Patrick Westermann, Christophe Lacroix, Susanne Loeliger, Jean-Charles Dalphin, Roger Lauener, Weronika Barcik, Charlotte Braun-Fahrländer, Martin Depner, Marcin Wawrzyniak, Elisa Schiavi, Caroline Roduit, Noelia Rodriguez-Perez, Liam O'Mahony, Juha Pekkanen, Claudio Rhyner, Ruth Ferstl, Remo Frei, Erika von Mutius, Josef Riedler
Přispěvatelé: Children's Hospital, University hospital of Zurich [Zurich], University of Ferrara at St. Anna Hospital, Università degli Studi di Ferrara = University of Ferrara (UniFE), Unité Mixte de Recherche sur le Fromage (UMRF), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Ludwig-Maximilians-Universität München (LMU), Asthma and Allergy Department, University Children's Hospital-Ludwig-Maximilians University [Munich] (LMU), University of Basel (Unibas), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Kardinal Schwarzenberg’sches Krankenhaus, Hochgebirgsklinik, Davos-Wolfgang, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Unité Mixte de Recherche Fromagère (UMRF), Institut National de la Recherche Agronomique (INRA), University Children's Hospital-Ludwig Maximilians University, Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), University of Zürich [Zürich] (UZH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE)
Rok vydání: 2018
Předmět:
Zdroj: Allergy
Allergy, 2018, ⟨10.1111/all.13660⟩
Allergy, Wiley, 2018, ⟨10.1111/all.13660⟩
ISSN: 1398-9995
0105-4538
Popis: Background Dietary changes are suggested to play a role in the increasing prevalence of allergic diseases and asthma. Short-chain fatty acids (SCFAs) are metabolites present in certain foods and are produced by microbes in the gut following fermentation of fibers. SCFAs have been shown to have anti-inflammatory properties in animal models. Our objective was to investigate the potential role of SCFAs in the prevention of allergy and asthma. Methods We analyzed SCFA levels by high-performance liquid chromatography (HPLC) in fecal samples from 301 one-year-old children from a birth cohort and examined their association with early life exposures, especially diet, and allergy and asthma later in life. Data on exposures and allergic diseases were collected by questionnaires. In addition, we treated mice with SCFAs to examine their effect on allergic airway inflammation. Results Significant associations between the levels of SCFAs and the infant's diet were identified. Children with the highest levels of butyrate and propionate (≥95th percentile) in feces at the age of one year had significantly less atopic sensitization and were less likely to have asthma between 3 and 6 years. Children with the highest levels of butyrate were also less likely to have a reported diagnosis of food allergy or allergic rhinitis. Oral administration of SCFAs to mice significantly reduced the severity of allergic airway inflammation. Conclusion Our results suggest that strategies to increase SCFA levels could be a new dietary preventive option for allergic diseases in children.
Databáze: OpenAIRE
Externí odkaz: