Antimicrobial approaches in the prevention of Staphylococcus aureus infections : a review
| Autor: | D P R Troeman, D van Hout, J. A. J. W. Kluytmans |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Staphylococcus aureus medicine.medical_specialty medicine.drug_class 030106 microbiology Antibiotics MEDLINE Mupirocin Review medicine.disease_cause law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Anti-Infective Agents Meta-Analysis as Topic Randomized controlled trial law medicine Journal Article Humans Pharmacology (medical) 030212 general & internal medicine Intensive care medicine Randomized Controlled Trials as Topic Pharmacology business.industry Chlorhexidine Staphylococcal Infections Antimicrobial Systematic review Infectious Diseases chemistry Carrier State business Systematic Reviews as Topic medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy, 74(2), 281–294. Oxford University Press Journal of Antimicrobial Chemotherapy |
| ISSN: | 0305-7453 |
| Popis: | Background The prophylactic application of antimicrobials that are active against Staphylococcus aureus can prevent infections. However, implementation in clinical practice is limited. We have reviewed antimicrobial approaches for the prevention of S. aureus infections. Methods We searched the Cochrane Central Register of Controlled Trials, PubMed/MEDLINE and EMBASE databases and trial registries using synonyms for S. aureus, infections and prevention as search terms. We included randomized controlled trials and systematic reviews only. Results Most studies were conducted with mupirocin. Mupirocin is effective in preventing S. aureus infections in patients receiving dialysis treatment and in surgical patients, particularly if the patients are carriers of S. aureus. The combination of mupirocin and chlorhexidine, but not chlorhexidine alone, is also effective against S. aureus infections. So far, vaccines have not proven successful in protecting against S. aureus infections. Regarding prophylactic povidone–iodine and systemic antibiotics, there is limited evidence supporting their effectiveness against S. aureus infections. Antimicrobial honey has not been proven to be more effective or non-inferior to mupirocin in protecting against S. aureus infections. Conclusions The current evidence supports the use of mupirocin as prophylaxis for preventing infections with S. aureus, particularly in carriers and in the surgical setting or in patients receiving dialysis treatment. Other antimicrobial agents have not been sufficiently proven to be effective so far, or have been proven ineffective. New trials with vaccines and anti-staphylococcal peptides are currently underway and may lead to new preventive strategies in the future. |
| Databáze: | OpenAIRE |
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