Incidence of BK polyomavirus infection after kidney transplantation is independent of type of immunosuppressive therapy

Autor: E. Achilles, S Scheidat, Nina Dietze, Bjoern Nashan, Lutz Fischer, Jun Li, Josephine Radtke, Friedrich Thaiss, Martina Koch
Rok vydání: 2015
Předmět:
Male
Basiliximab
medicine.medical_treatment
030232 urology & nephrology
030230 surgery
medicine.disease_cause
Gastroenterology
0302 clinical medicine
Risk Factors
Germany
Kidney transplantation
Incidence
Antibodies
Monoclonal
Immunosuppression
Induction Chemotherapy
Middle Aged
BK virus
Infectious Diseases
Female
Kidney Diseases
Immunosuppressive Agents
medicine.drug
Adult
medicine.medical_specialty
Recombinant Fusion Proteins
Calcineurin Inhibitors
Viremia
Nephropathy
Maintenance Chemotherapy
03 medical and health sciences
Internal medicine
medicine
Humans
Transplantation
Homologous
Everolimus
Aged
Retrospective Studies
Immunosuppression Therapy
Transplantation
Polyomavirus Infections
business.industry
Mycophenolic Acid
medicine.disease
Kidney Transplantation
Calcineurin
Tumor Virus Infections
BK Virus
Immunology
business
Zdroj: Transplant infectious disease : an official journal of the Transplantation Society. 18(6)
ISSN: 1399-3062
Popis: Background BK polyomavirus (BKV) infection and BKV nephropathy (BKVN) are risk factors for allograft function and survival. Methods We retrospectively analyzed BK viremia and BKVN in 348 patients who received a kidney transplantation donated after brain death (n = 232) or living donation (n = 116) between 2008 and 2013. 266 patients were treated with standard immunosuppression consisting of basiliximab induction, calcineurin inhibitor (CNI), and mycophenolate (MPA, n = 219) or everolimus (n = 47). 82 patients received more intense immunosuppression with lymphocyte depletion, CNI and MPA (n = 38) or everolimus (n = 44). Results BK viremia occurred in 33 (9.5%) patients in the first year and in 7 (2.0%) recipients in the second year after transplantation. BKVN occurred in 4 (1.1%) patients in the first year. Donor and recipient age, diabetes, previous transplantation, and type of transplantation (donated after brain death vs. living donation) were no risk factors (P>0.05). BK incidence did not differ depending on induction or maintenance immunosuppression. Conclusion Incidence of BK viremia is independent of recipient characteristics, type of transplantation as well as induction and maintenance immunosuppression. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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