Interferon-γ Severely Inhibits DNA Synthesis of Vaccinia Virus in a Macrophage Cell Line
| Autor: | Mariano Esteban, Zora Mělková |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
DNA Replication
Vaccinia virus Nitric Oxide Virus Cell Line Interferon-gamma Mice chemistry.chemical_compound Interferon Virology medicine Animals Poxviridae Interferon gamma Orthopoxvirus Dose-Response Relationship Drug biology DNA synthesis Macrophages Monocyte biology.organism_classification Molecular biology medicine.anatomical_structure chemistry DNA Viral Vaccinia medicine.drug |
| Zdroj: | Virology. 198:731-735 |
| ISSN: | 0042-6822 |
| DOI: | 10.1006/viro.1994.1087 |
| Popis: | Interferon-γ inhibits the growth of several viruses; however, the exact mechanism of this inhibition has not been clearly defined. In this report, we show that in a monocyte/macrophage cell line J774.G8 IFN-γ inhibits the growth of vaccinia virus (VV) in a dose-dependent manner. This inhibition is due to a block in VV DNA synthesis and correlates with an increased generation of reactive nitrogen intermediates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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