Effects of estradiol, cyproterone acetate, tibolone and raloxifene on uterus and aorta atherosclerosis in oophorectomized cholesterol-fed rabbits
| Autor: | A. Sanjuán, Carlos Ascaso, Geòrgia Escaramís, Imma Mercadé, Camil Castelo-Branco, Elena Casals, J J Vicente, Jaume Ordi, J. A. Vanrell, Marta Colodrón |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Arteriosclerosis Norpregnenes Ovariectomy Tibolone Antiandrogen General Biochemistry Genetics and Molecular Biology Cholesterol Dietary chemistry.chemical_compound Internal medicine medicine Animals Cyproterone Acetate Aorta Estradiol business.industry Estrogen Replacement Therapy Uterus Estradiol valerate Obstetrics and Gynecology Cyproterone acetate medicine.disease Menopause Disease Models Animal Endocrinology chemistry Estrogen Raloxifene Hydrochloride Ovariectomized rat Cyproterone Female Rabbits business medicine.drug |
| Zdroj: | Maturitas. 45(1) |
| ISSN: | 0378-5122 |
| Popis: | Background: Different hormonal replacement regimens are used for treating climacteric complaints; however, not all of them have the same clinical profile. Cardiovascular disease (CVD) is a major health problem and tibolone, raloxifene, estradiol (alone or with cyproterone acetate) have been added to cholesterol-fed rabbits to study atherosclerosis. Methods: A total of 48 cholesterol-fed New Zealand white rabbits were studied for 4 months. Forty rabbits underwent bilateral ovariectomy and the other eight were sham operated (group S). The ovariectomized rabbits were allocated to five groups of eight animals each receiving tibolone (Group T, 6 mg/day), raloxifene (R, 35 mg/day), estradiol valerate (E, 3 mg/day), estradiol valerate plus cyproterone acetate (EC, 3+0.5 mg/day, respectively), and no treatment for the control group (C). The sham group received no treatment too. Results: After 4 months the percentage of the extent of atherosclerosis in the aorta was 30.4% in C group, 24.5% in S group, 10.2% in T group, 30.3% in R group, 17.9% in E group and 28.1% in EC group (P |
| Databáze: | OpenAIRE |
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