Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
| Autor: | Rafid Salim Jabir, Johnson Stanslas, Gwo Fuang Ho, Muhammad Azrif Bin Ahmad Annuar |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty China Drug-Related Side Effects and Adverse Reactions Nausea Health Toxicology and Mutagenesis Clinical Biochemistry India Orosomucoid Antineoplastic Agents Breast Neoplasms Docetaxel Pharmacology 030226 pharmacology & pharmacy Biochemistry 03 medical and health sciences 0302 clinical medicine Breast cancer Predictive Value of Tests Internal medicine polycyclic compounds Mucositis Medicine Humans Adverse effect Stomatitis biology business.industry Malaysia Exanthema medicine.disease Prognosis Rash female genital diseases and pregnancy complications 030220 oncology & carcinogenesis biology.protein Vomiting Female Taxoids medicine.symptom business Biomarkers medicine.drug |
| Zdroj: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 23(2) |
| ISSN: | 1366-5804 |
| Popis: | Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carrier of docetaxel in the blood. Docetaxel has extensive binding (98%) to plasma proteins such as AAG, lipoproteins and albumin.To study the association between plasma AAG level and non-haematological AEs of docetaxel in Malaysian breast cancer patients of three major ethnic groups (Malays, Chinese and Indians).One hundred and twenty Malaysian breast cancer patients receiving docetaxel as single agent chemotherapy were investigated for AAG plasma level using enzyme-linked immunosorbent assay technique. Toxicity assessment was determined using Common Terminology Criteria of Adverse Events v4.0. The association between AAG and toxicity were then established.There was interethnic variation of plasma AAG level; it was 182 ± 85 mg/dl in Chinese, 237 ± 94 mg/dl in Malays and 240 ± 83 mg/dl in Indians. It was found that low plasma levels of AAG were significantly associated with oral mucositis and rash.This study proposes plasma AAG as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash. |
| Databáze: | OpenAIRE |
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