[Two cases of typhoid fever with reduced susceptibility to fluoroquinolones]
| Autor: | Kazumi Takinaga, Akifumi Imamura, Naohide Takayama, Gohta Masuda, Masayoshi Negishi, Atsushi Ajisawa, Sakae Takano, Takuya Adachi |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Nalidixic acid medicine.drug_class Cephalosporin India Drug resistance Salmonella typhi Typhoid fever Minimum inhibitory concentration Anti-Infective Agents Japan Internal medicine medicine Humans Typhoid Fever Child business.industry Drug Resistance Microbial General Medicine medicine.disease Quinolone Reduced susceptibility Female business medicine.drug Fluoroquinolones |
| Zdroj: | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 75(1) |
| ISSN: | 0387-5911 |
| Popis: | Two separate febrile Indian patients who reside in Japan and had recently returned from their country were diagnosed as suffering from typhoid fever. Fluoroquinolone therapy was clinically ineffective and the addition of a third-generation cephalosporin was required in each case. Each strain of Salmonella Typhi was resistant to nalidixic acid in vitro and also showed higher minimal inhibitory concentration to other quinolones than usual susceptible strains. Similar cases of typhoid fever responding poorly to quinolone treatment have been observed in the Indian subcontinent, south-east Asia and central Asia since the early 1990s, and potential spread by travelers into Japan is of serious concern. Although quinolones still remain the drugs of choice for treatment of typhoid fever, physicians should be aware of the possibility and implications of clinical treatment failure. |
| Databáze: | OpenAIRE |
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