Retinal vascular changes and right ventricular structure and function: the MESA-Right Ventricle and MESA-Eye studies
| Autor: | Barbara E.K. Klein, David A. Bluemke, Ronald Klein, Anthony C. Chyou, Mary Frances Cotch, Joao A.C. Lima, Amy Praestgaard, Tien Yin Wong, R. Graham Barr, Steven M. Kawut |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system endocrine system diseases 030204 cardiovascular system & hematology right ventricle Mesa 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Ventricular morphology pulmonary hypertension medicine computer.programming_language lcsh:RC705-779 retinal vasculature business.industry Retinal lcsh:Diseases of the respiratory system medicine.disease Pulmonary hypertension Retinal vessel medicine.anatomical_structure 030228 respiratory system chemistry Ventricle lcsh:RC666-701 cardiovascular system Cardiology Right ventricular structure business computer Research Article |
| Zdroj: | Pulmonary Circulation Pulmonary Circulation, Vol 9 (2018) |
| ISSN: | 2045-8940 2045-8932 |
| Popis: | Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated with RV morphology and function. RV end-diastolic mass (RVEDM), end-diastolic volume (RVEDV), end-systolic volume (RVESV), stroke volume (RVSV), and ejection fraction (RVEF) were assessed using cardiac magnetic resonance imaging (MRI) scans of 4204 participants without clinical cardiovascular disease at the baseline examination; retinal photography was obtained at the second examination. Mean diameters of retinal arterioles and venules were measured and summarized as central retinal vein and artery equivalents (“veins” and “arteries,” respectively). After adjusting for covariates, wider veins were associated with greater RVEDM and RVEDV in women ( P = 0.04 and P = 0.02, respectively), whereas there was an inverse association with RVEDV in men ( P = 0.02). In both sexes, narrower arteries were associated with lower RVEDM ( P |
| Databáze: | OpenAIRE |
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