β-Glucan: A dual regulator of apoptosis and cell proliferation
| Autor: | Firdous A. Khanday, Farooq Ahmad Masoodi, S. M. Wani, Adil Gani, Sajad Ahmad Mir |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Programmed cell death
beta-Glucans Regulator Apoptosis macromolecular substances 02 engineering and technology Biochemistry Cell wall 03 medical and health sciences Immune system Structural Biology medicine Animals Humans Immunologic Factors Molecular Biology 030304 developmental biology Cell Proliferation 0303 health sciences Cell growth Chemistry Cancer General Medicine 021001 nanoscience & nanotechnology medicine.disease Cell biology carbohydrates (lipids) stomatognathic diseases Cancer cell 0210 nano-technology |
| Zdroj: | International journal of biological macromolecules. 182 |
| ISSN: | 1879-0003 |
| Popis: | β-Glucans are polysaccharides generally obtained from the cell wall of bacteria, fungi, yeasts, and aleurone layer of cereals. β-Glucans are polymers, with β-1,3 glucose as core linear structure, but they differ in their main branch length, linkages and branching patterns, giving rise to high and low-molecular-weight β-glucans. They are well-known cell response modifiers with immune-modulating, nutraceutical and health beneficial effects, including anticancer and pro-apoptotic properties. β-Glucan extracts have shown positive responses in controlling tumor cell proliferation and activation of the immune system. The immunomodulatory action of β-glucans enhances the host's antitumor defense against cancer. In consonance with the above, many studies have shown that β-glucan treatment leads to the induction of apoptotic death of cancer cells. The ability of β-glucans to stimulate apoptotic pathways or the proteins involved in apoptosis prompting a new domain in cancer therapy. β-glucan can be a potential therapeutic agent for the treatment of cancer. However, there is a need to legitimize the β-glucan type, as most of the studies include β-glucan from different sources having different physicochemical properties. The body of literature presented here focuses on the effects of β-glucan on immunomodulation, proliferation, cell death and the possible mechanisms and pathways involved in these processes. |
| Databáze: | OpenAIRE |
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