Seeds of Buchholzia coriacea in Diet Mitigate Ischemic Reperfusion–Induced Gastric Ulceration in Experimental Rats
| Autor: | Adeola Temitope Salami, Samuel Babafemi Olaleye, Olugbenga Adeola Odukanmi, Tosan Peter Omayone, Omosola Fisayo Faniyan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Capparaceae Nitric Oxide 030226 pharmacology & pharmacy Gastric Acid Leukocyte Count 03 medical and health sciences 0404 agricultural biotechnology 0302 clinical medicine Malondialdehyde Animals Medicine Pharmacology (medical) Buchholzia coriacea Stomach Ulcer Rats Wistar Folk medicine Nutrition and Dietetics Traditional medicine Platelet Count Superoxide Dismutase business.industry Body Weight Stomach digestive oral and skin physiology Arteries 04 agricultural and veterinary sciences Catalase Animal Feed Constriction 040401 food science digestive system diseases Diet Rats Disease Models Animal Oxidative Stress Reperfusion Injury Seeds Ischaemia reperfusion Medicine Traditional business Phytotherapy Food Science |
| Zdroj: | Journal of Dietary Supplements. 15:842-859 |
| ISSN: | 1939-022X 1939-0211 |
| Popis: | Buchholzia coriacea (B. coriacea) seeds, in folk medicine, have been documented to prevent gastric ulceration though the mechanism is not fully elucidated. To clarify this, the gastro-healing activities were investigated using graded incorporation of B. coriacea seeds in the diet. Male Wistar rats (150-200 g) were divided into 7 groups (n = 15): unulcerated untreated control, ulcerated untreated control, unulcerated B. coriacea low (10%), ulcerated B. coriacea low (10%), nulcerated B. coriacea high (25%), ulcerated B. coriacea high (25%), and ulcerated omeprazole-treated groups. Rats were fed with B. coriacea diets for 7 weeks; thereafter, ulcer was induced by ischemic reperfusion method. Daily body weight, gastric acid secretion, hematological parameters, stomach ulcer score, and biochemical and histological analyses were evaluated on days 0, 3, and 7 post-ulcer induction. Results were subjected to one-way analysis of variance (ANOVA) and presented as mean ± standard error of the mean (SEM); p ≤.05 was considered significant. Significant decreases were observed in mean body weight of B. coriacea-fed compared with control and omeprazole-treated groups from week 7. Ulcerated B. coriacea-fed showed significant decrease in gastric acid secretion by days 3 and 7 compared with ulcerated control groups. Malondialdehyde content was significantly decreased in ulcerated B. coriacea-fed compared with control and omeprazole-treated groups. Significant increases in hematological variables (notably platelet count), superoxide dismutase, catalase, and nitric oxide levels of B. coriacea-fed compared with control and omeprazole-treated groups by days 0 and 3 were observed. Histological evaluations further confirmed these observations. B. coriacea diet enhanced gastric healing activities on ischemic reperfused gastric ulcer. Increased platelet count and nitric oxide levels may play significant roles in this process. |
| Databáze: | OpenAIRE |
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