The impact of shape memory test on degradation profile of a bioresorbable polymer
| Autor: | Magdalena Klim, Marian Domański, Michał Sobota, Anna Smola-Dmochowska, Michał Kawalec, Henryk Janeczek, Joanna Rydz, Marta Musioł, Michał Kwiecień, Jakub Wlodarczyk, Sebastian Jurczyk |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Hydrolysis Polyesters Bioresorbable polymers Biomedical Engineering Temperature Biocompatible Materials 02 engineering and technology Shape-memory alloy 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Permeability 0104 chemical sciences Biomaterials Crystallinity Polymer degradation Mechanics of Materials Drug release Degradation (geology) In vitro degradation Composite material Deformation (engineering) 0210 nano-technology Mechanical Phenomena |
| Zdroj: | Journal of the mechanical behavior of biomedical materials. 81 |
| ISSN: | 1878-0180 |
| Popis: | The semicrystalline poly(L-lactide) (PLLA) belongs to the materials with shape memory effect (SME) and as a bioresorbable and biocompatible polymer it have found many applications in medical and pharmaceutical field. Assessment of the SME impact on the polymer degradation profile plays crucial role in applications such as drug release systems or in regenerative medicine. Herein, the results of in vitro degradation studies of PLLA samples after SME full test cycle are presented. The samples were loaded and deformed in two manners: progressive and non-progressive. The performed experiments illustrate also influence of the material mechanical damages, caused e.g. during incorrect implantation of PLLA product, on hydrolytic degradation profile. Apparently, degradation profiles are significantly different for the material which was not subjected to the deformation and the deformed ones. The materials after deformation of 50% (in SME cycle) was characterized by non-reversible morphology changes. The effect was observed in deformed samples during the SME test which were carried out ten times. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect