Imbalance between the cellular proliferation and death in harderian gland of female mice with hyperprolactinemia
| Autor: | Manuel Simões, Ricardo Simoes, Osvaldo Pereira Araújo Júnior, Carina Verna, Regina Célia Teixeira Gomes, José Maria Soares Júnior, Edmund Chada Baracat, Ariadne Stavare Leal Araujo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
Programmed cell death medicine.medical_specialty Porphyrins animal structures Harderian gland Metoclopramide medicine.medical_treatment Mice R5-920 Stroma Fibrosis Internal medicine medicine Animals Saline Cell Proliferation TUNEL assay business.industry Harderian Gland Lacrimal Apparatus General Medicine medicine.disease Hyperprolactinemia Endocrinology Immunohistochemistry Female business Proliferation cell medicine.drug |
| Zdroj: | Revista da Associação Médica Brasileira v.67 n.5 2021 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB Revista da Associação Médica Brasileira, Vol 67, Iss 5, Pp 650-655 (2021) Revista da Associação Médica Brasileira, Volume: 67, Issue: 5, Pages: 650-655, Published: 17 JUL 2021 |
| Popis: | SUMMARY OBJECTIVE: To assess the impact of the metoclopramide-induced hyperprolactinemia in cellular death and proliferation in the harderian gland of female mice. METHODS: Twenty female mice were divided into two groups of 10 animals each and treated: 0.2 mL of saline solution (controls, Ctr) and 200 µg of metoclopramide (experimental, hyperprolactinemia), both for 50 consecutive days and at 12:00 a.m. On the 50th day, the female were euthanized, and the harderian glands were removed and processed for immunohistochemistry for detected ki67 and TUNEL method. Data were statistically analyzed by unpaired Student’s t test (p |
| Databáze: | OpenAIRE |
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