Synthesis of Medium Ring Heterocycles Using an Intramolecular Heck Reaction
| Autor: | Leggy A. Arnold, Guy Rk, Luo W |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Molecular Structure
Stereochemistry Organic Chemistry Chemistry Organic Alkylation Ring (chemistry) Highly selective Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound chemistry Cyclization Heterocyclic Compounds Heck reaction Intramolecular force Molecule Indicators and Reagents Physical and Theoretical Chemistry Azepine |
| Zdroj: | Organic Letters. 6:3005-3007 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol0487884 |
| Popis: | Historically, general convergent syntheses of medium ring heterocycles have been difficult to develop. Herein, we describe the synthesis of five classes of heterocycles: dihydrodibenzo[b,f]azepine, -oxocine, and -thiocine and dibenzo[b,f]azepine and -oxepine using a strategy of alkylation followed by highly selective intramolecular Heck arylation reaction. The hetero-tricyclic compounds were available in only two steps starting from commercially available starting materials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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