Analysis of the mRNA expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) in liver metastases from colorectal cancer
| Autor: | Takao Yamane, Shingo Kameoka, Akiyoshi Seshimo |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Colorectal cancer Orotate Phosphoribosyltransferase Mrna expression Thymidylate synthase Metastasis Dihydropyrimidine dehydrogenase medicine Humans RNA Messenger Dihydrouracil Dehydrogenase (NADP) Aged chemistry.chemical_classification Aged 80 and over Hepatology biology business.industry Liver Neoplasms Gastroenterology Phosphoribosyl transferase Cancer General Medicine Thymidylate Synthase Middle Aged medicine.disease Prognosis Enzyme Biochemistry chemistry biology.protein Cancer research Female Fluorouracil business Colorectal Neoplasms |
| Zdroj: | Hepato-gastroenterology. 60(122) |
| ISSN: | 0172-6390 |
| Popis: | BACKGROUND/AIMS We measured the mRNA expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) in liver metastases from colorectal cancer and retrospectively analyzed their association with other clinicopathological factors and the prognosis of these patients. METHODOLOGY The study involved 55 patients of colorectal cancer with liver metastasis who underwent surgery at our department between February 1988 and April 2003. RESULTS Analysis of the mRNA expression levels of each of the aforementioned enzymes in the liver metastases revealed no significant differences in the mRNA expression levels of the enzymes depending on the timing of development of the liver metastasis, histological type of the cancer, or the patient gender. In the analysis of the survival period, no association was observed between the survival prognosis and the mRNA expression level of DPD or OPRT in the liver metastases; on the other hand, the prognosis was better in the group showing low TS mRNA expression (median survival period: 3.77 years) than in the group showing high TS mRNA expression (median survival period: 2.39 years) (p=0.0134). CONCLUSIONS These results suggest that the mRNA expression level of TS in the liver metastases in colorectal cancer patients is a useful prognostic indicator. |
| Databáze: | OpenAIRE |
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