Changes in plasma phospholipid fatty acids and their relationship to disease activity in rheumatoid arthritis patients treated with a vegetarian diet
| Autor: | Kristian S. Bjerve, Arne Torbjørn Høstmark, Margaretha Haugen, Førre O, Kjeldsen-Kragh J |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Phospholipid Medicine (miscellaneous) Phospholipid fraction Arthritis Rheumatoid Disease activity chemistry.chemical_compound Internal medicine medicine Humans Single-Blind Method Prospective Studies Phospholipids chemistry.chemical_classification Baseline values Nutrition and Dietetics business.industry Diet Vegetarian Fatty Acids Significant difference Fatty acid Vegan Diet Middle Aged medicine.disease Endocrinology chemistry Biochemistry Rheumatoid arthritis Female business |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1079/bjn19940059 |
| Popis: | In a controlled clinical trial we have recently shown that patients with rheumatoid arthritis (RA) improved after fasting for 7–10 d and that the improvement could be sustained through 3.5 months with a vegan, diet and 9 months with a lactovegetarian diet. Other studies have indicated that the inflammatory process in R A can be reduced through manipulation of dietary fatty acids. A switch to a vegetarian diet significantly alters the intake of fatty acids. Therefore, we have analysed the changes in fatty acid profiles of the plasma phospholipid fraction and related these changes to disease activity. The concentrations of the fatty acids 20: 3n-6 and 20: 4n-6 were significantly reduced after 3.5 months with a vegan diet (P< 0.0001 andP< 0.01 respectively), but the concentration increased to baseline values with a lactovegetarian diet. The concentration of 20: 5n-3 was significantly reduced after the vegan diet (P< 0.0001) and the lactovegetarian diet periods (P< 0.01). There was no significant difference in fatty acid concentrations between diet responders and diet non-responders after the vegan or lactovegetarian diet periods. Our results indicate that the changes in the fatty acid profiles cannot explain the clinical improvement. |
| Databáze: | OpenAIRE |
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