Suppression by iron chelator phenanthroline of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine in Wistar rats
| Autor: | Masaharu Tatsuta, Hiroyuki Yano, Hiroyasu Iishi, Noriya Uedo, Tomiko Mikuni, Hiroyuki Narahara, Miyako Baba |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Methylnitronitrosoguanidine Cancer Research Phenanthroline Sodium Radical chemistry.chemical_element Apoptosis Adenocarcinoma Pharmacology Iron Chelating Agents chemistry.chemical_compound Antigens Neoplasm Stomach Neoplasms Proliferating Cell Nuclear Antigen Animals Rats Wistar Sodium Chloride Dietary Carcinogen Iron Chelator Cocarcinogenesis Hydroxyl Radical digestive oral and skin physiology Electron Spin Resonance Spectroscopy Drug Synergism In vitro Rats Oncology chemistry Biochemistry Hydroxyl radical Lipid Peroxidation Oxidation-Reduction Cell Division Phenanthrolines |
| Zdroj: | Cancer Letters. 191:9-16 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(01)00797-2 |
| Popis: | The effect of prolonged administration of iron chelator phenanthroline on sodium chloride-enhanced gastric carcinogenesis induced by N -methyl- N ′-nitro- N -nitrosoguanidine, and the labeling and apoptotic indices in the gastric cancers was investigated in Wistar rats. After 25 weeks of carcinogen treatment, the rats were given chow pellets containing 10% sodium chloride and intraperitoneal injections of phenanthroline at doses of 15 or 30 mg/kg body weight every other day. At week 52, feeding of sodium chloride significantly increased the incidence of gastric cancers, as compared with the control group. Prolonged injections of phenanthroline at both doses significantly reduced the incidence of gastric cancers, which was enhanced by oral supplementation with sodium chloride. Phenanthroline at both doses significantly decreased the labeling index of gastric cancers, which was enhanced by sodium chloride, and significantly increased the apoptotic index of gastric cancers, which was lowered by sodium chloride. In vitro examination using electron spin resonance revealed that sodium chloride promotes the production of hydroxyl radical during Fe 2+ oxidation by Fenton's reaction. These findings suggest that enhancement by sodium chloride of gastric carcinogenesis may be mediated by hydroxyl radicals. |
| Databáze: | OpenAIRE |
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