Two Decades of Deceased Donor Kidney Transplantation at Ahmedabad, India
| Autor: | Vivek B. Kute, Himanshu V. Patel, Pranjal R. Modi, Sayyad J. Rizvi, Pankaj R. Shah, Divyesh P. Engineer, Subho Banerjee, Bina P. Butala, Shruti Gandhi, Vineet V. Mishra |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent India 030230 surgery History 21st Century Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Risk Factors Living Donors Humans Medicine Organ donation Young adult Child Aged Retrospective Studies Aged 80 and over Disseminated intravascular coagulation Deceased donor kidney Transplantation Kidney business.industry Graft Survival Head injury Infant Retrospective cohort study Middle Aged medicine.disease Kidney Transplantation Tissue Donors Surgery Treatment Outcome surgical procedures operative medicine.anatomical_structure Child Preschool Female 030211 gastroenterology & hepatology business Program Evaluation |
| Zdroj: | Experimental and Clinical Transplantation. 18:549-556 |
| ISSN: | 2146-8427 1304-0855 |
| DOI: | 10.6002/ect.2020.0318 |
| Popis: | Objectives Gujarat, Tamil Nadu, Telangana, Maharashtra, Kerala, Chandigarh, and Karnataka are states in India with active programs for deceased donor kidney transplant. We report our experience of 2 decades of deceased donor kidney transplant at the Institute of Kidney Diseases and Research Center, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India. Materials and methods This single-center retrospective study comprised data from 831 deceased donor kidney transplant recipients between January 1, 1997 and December 31, 2018. Mean recipient age was 38 ± 14 years; 564 were male, and 267 were female. Mean donor age was 45.3 ± 17.13 years; 565 were men, and 266 were women. Results Between January 1, 1997 and March 15, 2020, 5838 kidney transplants were completed, including 4895 living donor kidney transplants, 943 deceased donor kidney transplants, and 440 kidney paired donation transplants. Over the mean follow-up time of 8 ± 5.4 years, patient survival rate was 70% (n = 581) and death-censored graft survival rate was 84% (n = 698). Delayed graft function was shown in 210 patients (25%) and biopsy-proven acute rejection rate in 180 patients (21%). Our experience of favorable outcomes with deceased donor kidney transplants has expanded the donor pool in many ways, including transplant from expanded criteria donors to younger recipients; transplant from older donors to older recipients; donation after cardiac death; successful intercity organ procurement; dual-kidney transplant; en bloc transplant from a pediatric deceased donor; and transplant from brain death deceased donors who died from neurotoxic snakebite, recurrent primary brain tumor, bacterial meningitis, or head injury, or with disseminated intravascular coagulation and deranged renal functions. The pathway to increase organ donation was investigated. Conclusions Deceased donor kidney transplant can achieve acceptable graft function with patient/graft survival, which may encourage the use of this approach to increase the number of available organs. |
| Databáze: | OpenAIRE |
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