The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials

Autor: Dongmei Wang, Hamed Kord-Varkaneh, Faezeh Poursoleiman, Maria Papageorgiou, Hui Li, Dongyang Han, Baoping Ma, Ali Nazary-Vannani, Feng Ding, Jamal Rahmani, Israel Júnior Borges do Nascimento, Somaye Fatahi
Rok vydání: 2020
Předmět:
Male
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Coffea
030204 cardiovascular system & hematology
Triglyceride
Gastroenterology
law.invention
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
law
Randomized Controlled Trials as Topic
Evidence-Based Medicine
Green-coffee
Nutrition and Dietetics
medicine.diagnostic_test
Anticholesteremic Agents
Bean extract
Lipid profile
Cholesterol
Treatment Outcome
Meta-analysis
Seeds
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
ddc:174.957
HDL
MEDLINE
030209 endocrinology & metabolism
LDL
03 medical and health sciences
Internal medicine
medicine
Humans
Green coffee
Triglycerides
Dyslipidemias
Plant Extracts
business.industry
Cholesterol
HDL
Cholesterol
LDL
Confidence interval
chemistry
Dietary Supplements
business
Biomarkers
Zdroj: Nutrition, metabolism, and cardiovascular diseases, Vol. 30, No 1 (2020) pp. 1-10
ISSN: 0939-4753
Popis: Background and aim: This systematic review and meta-analysis aimed to assess the effects of green coffee bean extract (GCBE) supplementation on lipid profile in adults. Methods and results: The PubMed/Medline, Scopus, Web of sciences, and Google Scholar were systematically searched for randomized controlled trials available in English and published before February 2019. The meta-analysis was conducted using fixed effects models, and between-study heterogeneity was assessed by Cochran's Q test and I2. A total of 17 effect sizes were included in the meta-analysis. Combined effect sizes on serum total cholesterol concentrations revealed significant effects of GCBE supplementation on serum total cholesterol [weighted mean difference (WMD): -4.51 mg/dL, 95% confidence interval (CI): -6.89, -2.12, p < 0.001], low density lipoprotein-cholesterol (LDL-C) (WMD: -4.38 mg/dL, 95% CI: -6.44, -2.31, p < 0.001), and high density lipoprotein-cholesterol (HDL-C) (WMD: 2.63 mg/dL, 95% CI: 2.20, 3.07, p < 0.001) compared to controls. Nevertheless, no significant changes were observed in serum triglycerides levels (WMD: -4.34 mg/dL, 95% CI: -9.00, 0.32, p = 0.068). Conclusion: The evidence from available studies suggests that the GCBE supplementation leads to significant reductions in total cholesterol, HDL-C, and LDL-C levels, and has modest, but, non-significant effects on triglycerides levels.
Databáze: OpenAIRE
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