Understanding the Risk Factors and Long-Term Consequences of Cisplatin-Associated Acute Kidney Injury: An Observational Cohort Study
| Autor: | Milani Sivagnanam, Zeenat Bhat, Kevin Ginsburg, Mona D. Doshi, Corey K. Treadway, Pravit Cadnapaphornchai, Shamit Chopra, Ammar Sukari, Ho-Sheng Lin, George H. Yoo |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology lcsh:Medicine Renal function Antineoplastic Agents Kidney Function Tests urologic and male genital diseases Nephrotoxicity Cohort Studies chemistry.chemical_compound Risk Factors medicine Humans lcsh:Science Retrospective Studies Creatinine Multidisciplinary business.industry lcsh:R Acute kidney injury Retrospective cohort study Acute Kidney Injury Middle Aged medicine.disease female genital diseases and pregnancy complications Surgery chemistry Head and Neck Neoplasms Concomitant lcsh:Q Female Cisplatin Complication business Research Article Cohort study |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 11, p e0142225 (2015) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0142225 |
| Popis: | Acute kidney injury (AKI) is a well-known complication of cisplatin-based chemotherapy; however, its impact on long-term patient survival is unclear. We sought to determine the incidence and risk factors for development of cisplatin-associated AKI and its impact on long-term renal function and patient survival. We identified 233 patients who received 629 cycles of high-dose cisplatin (99±9mg/m2) for treatment of head and neck cancer between 2005 and 2011. These subjects were reviewed for development of AKI. Cisplatin nephrotoxicity (CN) was defined as persistent rise in serum creatinine, with a concomitant decline in serum magnesium and potassium, in absence of use of nephrotoxic agents and not reversed with hydration. All patients were hydrated per protocol and none had baseline glomerular filtration rate (GFR) via CKD-EPI |
| Databáze: | OpenAIRE |
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