Ceftobiprole medocaril (BAL5788) treatment of experimental Haemophilus influenzae, Enterobacter cloacae, and Klebsiella pneumoniae murine pneumonia
| Autor: | Melanie M. Hein, Mark S. Rouse, James M. Steckelberg, Robin Patel, Paloma Anguita-Alonso |
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| Rok vydání: | 2005 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Klebsiella pneumoniae Cefepime Cephalosporin Ceftobiprole medicine.disease_cause Statistics Nonparametric Haemophilus influenzae Microbiology Mice Drug Resistance Bacterial Enterobacter cloacae medicine Pneumonia Bacterial Animals Tissue Distribution biology General Medicine medicine.disease biology.organism_classification Virology respiratory tract diseases Anti-Bacterial Agents Cephalosporins Pneumonia Infectious Diseases Models Animal Ceftriaxone Female Immunocompetence medicine.drug |
| Zdroj: | Diagnostic microbiology and infectious disease. 55(4) |
| ISSN: | 0732-8893 |
| Popis: | Ceftobiprole (BAL9141) is an investigational cephalosporin active against methicillin- and vancomycin-resistant staphylococci administered as a water-soluble prodrug, ceftobiprole medocaril (BAL5788). Using an immunocompetent murine pneumonia model of Haemophilus influenzae , Enterobacter cloacae , or extended-spectrum β-lactamase (ESBL) nonproducing or producing Klebsiella pneumoniae pneumonia, we compared results of treatment with ceftobiprole medocaril (71 mg/kg, sc, qid), ceftriaxone (50 mg/kg, im, bid), or cefepime (50 mg/kg, ip, q.i.d.). Results were expressed as median and 25th to 75th percentile log 10 colony forming units per gram of lung tissue. Ceftobiprole, ceftriaxone, and cefepime were each more active than was no treatment and were equally active for treatment of experimental H. influenzae , E. cloacae , or ESBL-nonproducing K. pneumoniae pneumonia. For ESBL-producing K. pneumoniae , no differences were detected between no treatment and treatment with ceftobiprole, ceftriaxone, or cefepime. Ceftobiprole is active against H. influenzae , E. cloacae , and ESBL-nonproducing K. pneumoniae in an immunocompetent experimental murine pneumonia model. |
| Databáze: | OpenAIRE |
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