Supplementary Figure Legends from Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence

Autor: Jeffrey N. Myers, Olivier Lichtarge, Raymond E. Meyn, Marek Kimmel, Thomas O. McDonald, Teng-Kuei Hsu, Carlos Caulin, Sang Hyeok Woo, Mitchell J. Frederick, David M. Neskey, Alison L. Fitzgerald, Panagiotis Katsonis, Ameeta A. Patel, Marcus V. Ortega Alves, Marcus M. Monroe, Abdullah A. Osman
Rok vydání: 2023
DOI: 10.1158/1535-7163.22503730
Popis: The Wee-1 inhibitor, MK-1775 Synergizes with cisplatin in vitro in established HNSCC cell lines with known TP53 mutational status; Dual phospho-H3 staining and PI flow cytometric analysis (FACS); The synergy between cisplatin and MK-1775 in HNSCC is not mediated by apoptosis.
Databáze: OpenAIRE