Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease
| Autor: | Roger Chout, Olivier Hue, Danièle Mougenel, Eric Beltan, Julien Tripette, Maryse Etienne-Julan, Tawfik Chalabi, Tamas Alexy, Philippe Connes, Marie-Dominique Hardy-Dessources, Herbert J. Meiselman |
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| Rok vydání: | 2009 |
| Předmět: |
Erythrocyte Aggregation
medicine.medical_specialty Erythrocytes Blood viscosity Hemoglobin Sickle Anemia Sickle Cell Hematocrit Blood cell Internal medicine Erythrocyte Deformability medicine Humans Sickle cell trait medicine.diagnostic_test Chemistry Homozygote Hemoglobin C Fibrinogen Red blood cell distribution width Biological Transport Hematology medicine.disease Blood Viscosity Hemoglobin C Disease Sickle cell anemia Oxygen Red blood cell medicine.anatomical_structure Endocrinology Immunology Hemorheology Original Article |
| Zdroj: | Haematologica. 94(8) |
| ISSN: | 1592-8721 |
| Popis: | Background Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease. Design and Methods We compared red blood cell aggregation characteristics, blood viscosity and HVR at different shear rates between sickle cell anemia and sickle cell hemoglobin C disease (SCC) patients, sickle cell trait carriers (AS) and control individuals (AA). Results Blood viscosity determined at high shear rate was lower in sickle cell anemia (n=21) than in AA (n=52), AS (n=33) or SCC (n=21), and was markedly increased in both SCC and AS. Despite differences in blood viscosity, both sickle cell anemia and SCC had similar low HVR values compared to both AA and AS. Sickle cell anemia (n=21) and SCC (n=19) subjects had a lower red blood cell aggregation index and longer time for red blood cell aggregates formation than AA (n=16) and AS (n=15), and a 2 to 3 fold greater shear rate required to disperse red blood cell aggregates. Conclusions The low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Red blood cell aggregation properties are likely to be involved in the pathophysiology of sickle cell disease: the increased shear forces needed to disperse red blood cell aggregates may disturb blood flow, especially at the microcirculatory level, since red blood cell are only able to pass through narrow capillaries as single cells rather than as aggregates. |
| Databáze: | OpenAIRE |
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