TRPC5 channels participate in pressure-sensing in aortic baroreceptors
| Autor: | Yu Huang, Bing Shen, John A. Rudd, Wing-Ho Yung, Hui Chuan Wang, Chun Yin Lo, Man-Lung Fung, On Chai Lau, Xiaoqiang Yao, Yangchao Chen, Yung Wui Tjong, Ching On Wong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Baroreceptor Science General Physics and Astronomy Baroreflex Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences medicine.artery Internal medicine Heart rate medicine Myocardial infarction Aorta Multidisciplinary business.industry musculoskeletal neural and ocular physiology General Chemistry Anatomy medicine.disease Stretch-activated ion channel 030104 developmental biology Blood pressure nervous system Heart failure Cardiology cardiovascular system business circulatory and respiratory physiology |
| Zdroj: | Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Blood pressure is maintained within a normal physiological range by a sophisticated regulatory mechanism. Baroreceptors serve as a frontline sensor to detect the change in blood pressure. Nerve signals are then sent to the cardiovascular control centre in the brain in order to stimulate baroreflex responses. Here, we identify TRPC5 channels as a mechanical sensor in aortic baroreceptors. In Trpc5 knockout mice, the pressure-induced action potential firings in the afferent nerve and the baroreflex-mediated heart rate reduction are attenuated. Telemetric measurements of blood pressure demonstrate that Trpc5 knockout mice display severe daily blood pressure fluctuation. Our results suggest that TRPC5 channels represent a key pressure transducer in the baroreceptors and play an important role in maintaining blood pressure stability. Because baroreceptor dysfunction contributes to a variety of cardiovascular diseases including hypertension, heart failure and myocardial infarction, our findings may have important future clinical implications. The identity of mechanosensors within aortic baroreceptors that sense fluctuations in blood pressure is unclear. Here, Lau et al. show that a cation channel TRPC5 acts as a transducer of mechanical stimuli in aortic baroreceptor neurons in rodents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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