| Autor: |
Gaetano Chirico, Iolanda Mazzucchelli, M.A. Avanzini, G. Sabatino, Francesca Garofoli, Mauro Stronati, Tiziana Figar, Laura Ciardelli, Antonella Gasparoni, A. De Silvestri |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
International Journal of Immunopathology and Pharmacology. 21:781-786 |
| ISSN: |
2058-7384 |
| DOI: |
10.1177/039463200802100402 |
| Popis: |
Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn “virgin” immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest percentage of IFN-γ producing cells was in cytotoxic cells (p=0.0048), while no difference was found for IL-10. Cord blood samples consisted of a statistically significant greater percentage of helper than cytotoxic cells (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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