RPA, RFWD3 and BRCA2 at stalled forks: a balancing act
| Autor: | Shailja Pathania, Haohui Duan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Cancer Research endocrine system diseases Replication stress Computer science female genital diseases and pregnancy complications Fork (software development) Cell biology enzymes and coenzymes (carbohydrates) 03 medical and health sciences 0302 clinical medicine Author’s Views Molecular Medicine skin and connective tissue diseases 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Mol Cell Oncol |
| ISSN: | 2372-3556 |
| Popis: | We recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guarantee fork repair. These findings provide new insights into the workings of BRCA1 and BRCA2 in the stalled fork repair pathway. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|