Prospective Clinical Evaluation of Intra-Articular Injection of Tin-117m (117mSn) Radiosynoviorthesis Agent for Management of Naturally Occurring Elbow Osteoarthritis in Dogs: A Pilot Study
| Autor: | Michelle Fabiani, Brian S. Beale, Mandi J. Lopez, Frank M. Andrews, Chin-Chi Liu, Lorrie Gaschen, Karanvir S. Aulakh, Caleb C. Hudson, Jimmy Lattimer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
040301 veterinary sciences
Radiography Elbow Osteoarthritis medicine.disease_cause Weight-bearing 0403 veterinary science CBPI Intra articular medicine Adverse effect Prospective cohort study Original Research peak vertical force business.industry 0402 animal and dairy science Research and Reports [Veterinary Medicine] 04 agricultural and veterinary sciences medicine.disease 040201 dairy & animal science osteoarthritis medicine.anatomical_structure Radiosynoviorthesis Anesthesia Gait analysis Tin-117m (117mSn) business goniometry |
| Zdroj: | Veterinary Medicine : Research and Reports |
| ISSN: | 2230-2034 |
| Popis: | Karanvir S Aulakh,1 Mandi J Lopez,1 Caleb Hudson,2 Lorrie Gaschen,1 Michelle Fabiani,2 Brian Beale,2 Frank M Andrews,1 Chin-Chi Liu,1 Jimmy Lattimer3 1School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA; 2Gulf Coast Veterinary Specialists, Houston, TX, USA; 3College of Veterinary Medicine, University of Missouri, Columbia, MO, USACorrespondence: Karanvir S AulakhSchool of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USATel +1 217-722-2937Email kaulakh@lsu.eduPurpose: To evaluate the clinical effects of an intra-articular injection of 117mSn-colloid for management of canine grade 1 or 2 elbow osteoarthritis (OA).Patients and Methods: This was a prospective study in 23 dogs with grade 1 or 2 elbow OA. An orthopedic examination and elbow radiographs were performed to confirm the presence of OA. Dogs were randomly assigned to receive unilateral intra-articular (IA) injection of low-dose (LD: 1.0mCi, n =8), medium-dose (MD: 1.75mCi, n =6), or high-dose (HD: 2.5mCi, n =9) of 117mSn-colloid. The primary outcome measure was peak vertical force (PVF) from force-plate gait analysis and secondary outcome measures included the Canine Brief Pain Inventory score (CBPI) and elbow goniometry. The CBPI was evaluated at pretreatment and then monthly post treatment for 1 year, and goniometry and PVF were evaluated at pretreatment, and at 1, 3, 6, 9 and 12 months post treatment.Results: PVF improved at 3, and 9 months compared to pretreatment values in the HD group. CBPI scores improved at most of the time points in all dose groups. There was no significant difference in elbow goniometry between treated and untreated elbows. There were no self-reports of any adverse effects of the injection by the owners and none were noted by the examining veterinarian at the time of regularly scheduled re-evaluations.Conclusion: 117mSn IA injection was free of any obvious adverse effects, improved CBPI scores, and increased weight bearing in limbs with elbow OA providing preliminary evidence that 117mSn may be beneficial in the management of elbow OA in dogs. Although 17mSn appeared to be effective for management of elbow OA in these dogs, this pilot study has inherent limitations; therefore, future studies with larger numbers and with placebo group are needed.Keywords: osteoarthritis, Radiosynoviorthesis, Tin-117m (117mSn), CBPI, goniometry, peak vertical force |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|