Pre-Diagnosis Exercise and Cardiovascular Events in Primary Breast Cancer
| Autor: | Lee W. Jones, Andres Palomo, Bette J. Caan, Tochi M. Okwuosa, Roberta M. Ray, Randi E. Foraker, Electra D. Paskett, Lisa Johnson |
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| Rok vydání: | 2019 |
| Předmět: |
lcsh:Diseases of the circulatory (Cardiovascular) system
TIA transient ischemic attack medicine.medical_specialty BMI body mass index Physical activity physical activity HT hormone therapy lcsh:RC254-282 HF heart failure cardiovascular events breast cancer Breast cancer cardiovascular disease PAD peripheral arterial disease MET metabolic equivalent task Internal medicine Medicine OS observational study IQR interquartile range Original Research MI - Myocardial infarction CRF cardiorespiratory fitness exercise Women’s Health Initiative business.industry Women's Health Initiative HF - Heart failure survivors CVE cardiovascular event lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Oncology lcsh:RC666-701 MI myocardial infarction CT clinical trial Cardiology and Cardiovascular Medicine business Primary breast cancer WHI Women’s Health Initiative BMI - Body mass index |
| Zdroj: | JACC: CardioOncology JACC. CardioOncology, Vol 1, Iss 1, Pp 41-50 (2019) |
| ISSN: | 2666-0873 |
| Popis: | Objectives The purpose of this study was to investigate whether pre-diagnosis exercise reduces the risk of subsequent cardiovascular events (CVEs) in women with primary breast cancer. Background Cardiovascular disease (CVD) is the leading nonmalignant cause of death in patients with cancer, and it is the leading cause of death in women with primary breast cancer who are older than 65 years of age. Methods Using a prospective design, 4,015 patients with confirmed diagnosis of primary breast cancer enrolled in the Women’s Health Initiative (WHI) completed a self-report questionnaire assessing leisure-time physical activity (i.e., exercise) in metabolic equivalent task (MET) hours per week. Age- and multivariable-adjusted Cox proportional hazards models were used to estimate associations between pre-diagnosis exercise and new-onset CVEs (i.e., heart failure [HF], myocardial infarction [MI], angina, coronary revascularization, peripheral arterial disease [PAD], carotid artery disease, transient ischemic attack [TIA], stroke, and cardiovascular death). Results Median follow-up was 12.7 years and 8.2 years for cardiovascular disease (CVD) mortality and CVEs, respectively, with 324 CVEs, including 89 MIs, 49 new diagnoses of HF, and 215 CVD deaths. In multivariable analysis, the incidence of composite CVEs decreased across increasing total MET h/week categories (p = 0.016). Compared with Central Illustration |
| Databáze: | OpenAIRE |
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