Circulating hematopoietic progenitor cells in polycythemia vera: The in vivo effect of hydroxyurea
| Autor: | Cerruti A, Ivo Pannacciulli, D. Cavallini, Giuseppe Bogliolo, Roberto Lerza, Castello G |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Myeloid Clone (cell biology) Cell Count Colony-Forming Units Assay Hydroxycarbamide Polycythemia vera In vivo hemic and lymphatic diseases Internal medicine medicine Humans Hydroxyurea Progenitor cell Polycythemia Vera Aged Hematology business.industry General Medicine Middle Aged Hematopoietic Stem Cells medicine.disease medicine.anatomical_structure Endocrinology Stem cell business Follow-Up Studies circulatory and respiratory physiology medicine.drug |
| Zdroj: | Annals of Hematology. 71:119-121 |
| ISSN: | 1432-0584 0939-5555 |
| DOI: | 10.1007/bf01702646 |
| Popis: | The in vivo effects of hydroxyurea (HU) on circulating erythroid (BFU-E) and granulocyte-macrophage progenitors (CFU-GM) in patients with polycythemia vera (PV) have been evaluated. HU induced a strong decrease of both BFU-E and CFU-GM in the first month of treatment. During the following 4 months of treatment the level of circulating progenitors remained at very low values, until the end of the period of observation. HU activity involved both erythroid and myeloid committed progenitors and both erythropoietin-stimulated (normal) and endogenous (derived from the abnormal PV clone) BFU-E. |
| Databáze: | OpenAIRE |
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