Pharmacological and pathophysiological effects of periadventitial stripping on immediate and subacute postoperative vasoconstriction in guinea pigs
| Autor: | Kemali Baykaner, Ömer Uluoğlu, Necdet Çeviker, I. Semih Keskil, Zeynep Sevim Ercan, Hizir Alp |
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| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Microsurgery Guinea Pigs Nitric Oxide Guinea pig chemistry.chemical_compound Adventitia Culture Techniques Medicine Animals business.industry Endothelium-derived relaxing factor Vasospasm General Medicine medicine.disease Pathophysiology Surgery Blood pressure medicine.anatomical_structure chemistry Ischemic Attack Transient Vasoconstriction Anesthesia Female Neurology (clinical) Endothelium Vascular medicine.symptom business Carotid Artery Internal Artery |
| Popis: | Mechanically induced vasospasm observed in the immediate post-operative period was investigated, and the effect of factors such as temporary clip applications and post-operative intervals were studied. Guinea pig "cervical internal carotid arteries" were used and temporary clips, chosen according to the diameter of the artery and systolic pressure, were applied for a standard period. The same procedure was applied on arteries in which periadventitial tissue had been removed using appropriate microsurgical techniques. On postoperative days 1, 5, and 10, arterial rings were removed while the animals were still alive and Endothelium Dependent Relaxations were measured using a bioassay system. Morphological investigations were also performed using light microscopy on the same arterial preparations. We observed no difference between perioperative and first day postoperative results. The relaxations were minimum. The most striking pathological changes were observed on postoperative day 5, and the relaxation responses began to rise on day 10 together with morphological improvement. It was also found that periadventitial tissue stripping could be used to prevent subacute post-operative vasoconstriction, since its effect was marked on postoperative day 5 and began to resolve on day 10. |
| Databáze: | OpenAIRE |
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