Non-multidrug-resistant, methicillin-resistant Staphylococcus aureus in a neonatal unit
| Autor: | Gabriela F. Raymundo, Renata D. Lobo, Anna S. Levin, Matias Chiarastelli Salomão, S. Gobara, Vera Lúcia Jornada Krebs, Maria A. Cursino, M. Augusta Gibelli, Cilmara P. Garcia, Robson E. Soares, Kleiste G. Keil, Silvia Figueiredo Costa, M. Helena Matté, Juliana Ferraz Rosa, Marcelo Zugaib, Edi Toma, Carla H. Mollaco, Paula B. Malieno, Mário M. Kondo |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Adult Male Methicillin-Resistant Staphylococcus aureus medicine.medical_specialty Genotype medicine.disease_cause Cohort Studies Internal medicine medicine Infection control Humans Prospective Studies Risk factor Molecular Epidemiology business.industry SCCmec Infant Newborn Odds ratio Staphylococcal Infections Methicillin-resistant Staphylococcus aureus Confidence interval Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field Molecular Typing Infectious Diseases Pediatrics Perinatology and Child Health Carrier State Female business Breast feeding Cohort study |
| Zdroj: | The Pediatric infectious disease journal. 33(10) |
| ISSN: | 1532-0987 |
| Popis: | Background In the last decade, non-multiresistant methicillin-resistant Staphylococcus aureus (NM-MRSA) has been described as an important agent in bloodstream infections in our hospital. Methods This prospective cohort study, conducted from February 2009 through January 2010 in the neonatal unit, evaluated 403 newborns (NB), their 382 mothers and 148 health care workers (HCW). Results Approximately 217 NB (54%), 187 mothers (48%) and 87 HCW (59%) were colonized by S. aureus (SA). MRSA colonization was greater among NB (15%) than mothers (4.7%) and HCW (3.4%). Although mother-to-NB transmission occurred, in most cases mothers were not responsible for NB colonization. There were 2 predominant PFGE patterns among the NB and some mothers and HCW became colonized by them. Factors significantly associated with MRSA carriage by NB were lower level of maternal schooling (risk factor: odds ratio: 2.99; 95% confidence interval: 1.10-8.07) and maternal rhinosinusitis (protective factor: odds ratio: 0.33; 95% confidence interval:0.12-0.88). Among NB who remained hospitalized for more than 72 hours, breast feeding was protective (odds ratio: 0.22; 95% confidence interval: 0.05-0.98). All the isolates were NM-MRSA, carried few virulence factors and SCCmec types IVa and type IVd predominated. Conclusions Although there were no cases of infection, nosocomial transmission of MRSA clearly occurred in the neonatal unit, and this highlights the need for infection control practices such as hand hygiene to prevent cross-dissemination. Other healthcare practices, which are very basic but also ample in scope, may play a role, such as general education of women and breast feeding. |
| Databáze: | OpenAIRE |
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