BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF-κB pathway—A comparative study with curcumin
| Autor: | Mohane Selvaraj Coumar, Dinesh Babu Somasundaram, Kumaravel Mohankumar, Latha Periyasamy, Rukkumani Rajagopalan, Akhil C. Banerjea, Vivek Singh, Subhashree Sridharan, Sankar Pajaniradje, Larance Ronsard |
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| Rok vydání: | 2015 |
| Předmět: |
Curcumin
Angiogenesis Breast Neoplasms Metastasis chemistry.chemical_compound Breast cancer medicine Anticarcinogenic Agents Humans Computer Simulation Neoplasm Invasiveness Neoplasm Metastasis Pharmacology Neovascularization Pathologic business.industry NF-kappa B NF-κB General Medicine medicine.disease In vitro Molecular Docking Simulation chemistry MCF-7 Docking (molecular) Immunology MCF-7 Cells Cancer research Female business Signal Transduction |
| Zdroj: | Biomedicine & Pharmacotherapy. 74:178-186 |
| ISSN: | 0753-3322 |
| Popis: | Breast cancer chemoprevention has become increasingly important in India as it faces a potential breast cancer epidemic over the next decade. Curcumin, the active ingredient in turmeric is a well known chemopreventive agent that possesses various therapeutic properties including antioxidants and anti-inflammatory effects. In the present study, we have investigated the inhibitory effects of BDMC-A, an analog of curcumin, on invasion, angiogenesis and metastasis markers using in vitro with MCF-7 cells and in silico studies, hence proved that BDMC-A has more potential than curcumin. Mechanistic studies revealed that BDMC-A might have exerted its activity by inhibiting metastatic and angiogenic pathways by modulating the expression of proteins upstream to NF-κB (TGF-β, TNF-α, IL-1β and c-Src), and NF-κB signaling cascade (c-Rel, COX-2, MMP-9, VEGF, IL-8) and by upregulating TIMP-2 levels. An in silico molecular docking study with NF-κB revealed that the docking score and interaction of BDMC-A with NF-κB-DNA binding was more efficient when compared to curcumin. Our overall results showed that BDMC-A more effectively inhibited invasion, angiogenesis and metastasis markers compared to curcumin. The activity can be attributed to the presence of hydroxyl group in the ortho position in its structure. Further research are going on to prove its potential as a therapeutic agent for breast cancer. |
| Databáze: | OpenAIRE |
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