Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish
| Autor: | Raghavendra Kikkeri, Raghavendra Vasudeva Murthy, Balamurugan Subramani, Preeti Madhukar Chaudhary, Suraj Toraskar, Sivakoti Sangabathuni |
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| Rok vydání: | 2017 |
| Předmět: |
Biodistribution
Science Metal Nanoparticles Nanotechnology 02 engineering and technology 010402 general chemistry Bioinformatics 01 natural sciences Article Drug Delivery Systems Polysaccharides Basic research In vivo Animals Humans Tissue Distribution High order Zebrafish Multidisciplinary biology Chemistry 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Colloidal gold Models Animal Toxicity Drug delivery Medicine Gold 0210 nano-technology Mannose |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-03350-3 |
| Popis: | Glyconanotechnology offers a broad range of applications across basic and translation research. Despite the tremendous progress in glyco-nanomaterials, there is still a huge gap between the basic research and therapeutic applications of these molecules. It has been reported that complexity and the synthetic challenges in glycans synthesis, the cost of the high order in vivo models and large amount of sample consumptions limited the effort to translate the glyco-nanomaterials into clinical applications. In this regards, several promising simple animal models for preliminary, quick analysis of the nanomaterials activities has been proposed. Herein, we have studied a systematic evaluation of the toxicity, biodistribution of fluorescently tagged PEG and mannose-capped gold nanoparticles (AuNPs) of three different shapes (sphere, rod, and star) in the adult zebrafish model, which could accelerate and provide preliminary results for further experiments in the higher order animal system. ICP-MS analysis and confocal images of various zebrafish organs revealed that rod-AuNPs exhibited the fast uptake. While, star-AuNPs displayed prolong sequestration, demonstrating its potential therapeutic efficacy in drug delivery. |
| Databáze: | OpenAIRE |
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