Remote preconditioning, perconditioning, and postconditioning: a comparative study of their cardio-protective properties in rat models
| Autor: | Yu Zhu, Wei Jiang, Jian Zhu, Rong-Ping Wang, Yong Liu, Gui-Lin Yin, Shui-Bo Zhu, Yu Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Rat model Ischemia Myocardial Infarction Myocardial Reperfusion Injury Random Allocation Left coronary artery Models Internal medicine medicine.artery medicine Animals Ventricular Function Myocardial infarction Rats Wistar lcsh:R5-920 Tourniquet business.industry Arrhythmias Cardiac General Medicine Ischemia^i1^sReperfusion Inj Cardioprotective Property medicine.disease Rats Basic Research Treatment Outcome Ischemia/Reperfusion Injury Anesthesia Ischemic Preconditioning Myocardial Cardiology Ischemic preconditioning lcsh:Medicine (General) Ligation business Reperfusion injury |
| Zdroj: | Clinics, Volume: 68, Issue: 2, Pages: 263-268, Published: 2013 Clinics; v. 68 n. 2 (2013); 263-268 Clinics; Vol. 68 Núm. 2 (2013); 263-268 Clinics; Vol. 68 No. 2 (2013); 263-268 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Vol 68, Iss 2, Pp 263-268 (2013) |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVE: Ischemia reperfusion injury is partly responsible for the high mortality associated with induced myocardial injury and the reduction in the full benefit of myocardial reperfusion. Remote ischemic preconditioning, perconditioning, and postconditioning have all been shown to be cardioprotective. However, it is still unknown which one is the most beneficial. To examine this issue, we used adult male Wistar rat ischemia reperfusion models to compare the cardioprotective effect of these three approaches applied on double-sided hind limbs. METHODS: The rats were randomly distributed to the following five groups: sham, ischemia reperfusion, remote preconditioning, remote perconditioning, and remote post-conditioning. The ischemia/reperfusion model was established by sternotomy followed by a 30-min ligation of the left coronary artery and a subsequent 3-h reperfusion. Remote conditioning was induced with three 5-min ischemia/5-min reperfusion cycles of the double-sided hind limbs using a tourniquet. RESULTS: A lower early reperfusion arrhythmia score (1.50 + 0.97) was found in the rats treated with remote perconditioning compared to those in the ischemia reperfusion group (2.33 + 0.71). Meanwhile, reduced infarct size was also observed (15.27 + 5.19% in remote perconditioning, 14.53 + 3.45% in remote preconditioning, and 19.84+5.85% in remote post-conditioning vs. 34.47 + 7.13% in ischemia reperfusion, p |
| Databáze: | OpenAIRE |
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