Ascitic fluid gamma interferon concentrations and adenosine deaminase activity in tuberculous peritonitis
| Autor: | P. N. Soni, S. A. H. Moola, Y. M. Coovadia, F. Makumbi, A. E. Simjee, Mahomed A. Sathar, B. Insam |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Cirrhosis Tuberculosis Adolescent Adenosine Deaminase Peritonitis Tuberculous Peritonitis Gastroenterology Interferon-gamma Adenosine deaminase Internal medicine Ascites medicine Ascitic Fluid Humans Interferon gamma Prospective Studies Prospective cohort study Aged biology business.industry Middle Aged medicine.disease Effusion Immunology biology.protein medicine.symptom business Research Article medicine.drug |
| Zdroj: | Gut. 36:419-421 |
| ISSN: | 0017-5749 |
| Popis: | The gamma interferon (gamma-IFN) concentration and the adenosine deaminase (ADA) activity were evaluated in 30 patients with tuberculous peritonitis, 21 patients with ascites due to a malignant disorder, and 41 patients with cirrhosis. The gamma-IFN concentrations were significantly higher (p < 0.0001) in tuberculous peritonitis patients (mean: 6.70 U/ml) than in the malignant (mean: 3.10 U/ml) and cirrhotic (mean: 3.08 U/ml) groups. Use of a cut off value of > or = 3.2 U/ml gave the assay a sensitivity of 93% (25 of 27), a specificity of 98% (54 of 55), positive (P+) and negative (P-) predictive values of 96% and a test accuracy of 96%. The ADA activity was significantly (p < 0.0001) higher in the tuberculous peritonitis group (mean: 101.84 U/l) than in the control groups (cirrhosis (mean: 13.49 U/l) and malignancy (mean: 19.35 U/l)). A cut off value of > 30 U/l gave the ADA test a sensitivity of 93% (26 of 28) a specificity of 96% (51 of 53), a (P+) value of 93%, a (P-) value of 96%, and a test accuracy of 95%. There was a significant (p < 0.0001) correlation (r = 0.72) between ADA activity and gamma-IFN values in patients with tuberculous peritonitis. These results show that a high concentration of gamma-IFN in ascitic fluid is as valuable as the ADA activity in the diagnosis of tuberculous peritonitis. Both are rapid non-invasive diagnostic tests for tuberculous peritonitis. |
| Databáze: | OpenAIRE |
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