A single postoperative application of nitroglycerin ointment does not increase survival of cutaneous flaps and grafts
| Autor: | John A. Zitelli, Michael J. Fazio, David G. Brodland, Michael J. Huether, Cary L. Dunn, Robert D. Griego |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Skin Neoplasms medicine.medical_treatment Vasodilator Agents Treatment outcome Dermatology Biological effect Administration Cutaneous Disease-Free Survival Surgical Flaps Ointments Nitroglycerin Double-Blind Method medicine Mohs surgery Humans cardiovascular diseases Postoperative Care Chemotherapy Wound Healing business.industry Graft Survival General Medicine Skin Transplantation Mohs Surgery Skin transplantation eye diseases Surgery surgical procedures operative Treatment Outcome Vasodilator agents Anesthesia cardiovascular system Graft survival business circulatory and respiratory physiology |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 26(5) |
| ISSN: | 1076-0512 |
| Popis: | Nitroglycerin is a vasodilator that has been reported to improve cutaneous flap and graft survival. It has not been tested in controlled studies.We designed our study to test the effectiveness of a single postoperative application of nitroglycerin on flap and graft survival.Eighty-eight surgical repairs received topical nitroglycerin and 85 received control ointment (polysporin). Treatment sites were evaluated on postoperative day 7 and assigned a percentage of surface area survival.There was no significant difference in the complication rate of flaps and grafts treated with nitroglycerin (12.5%) compared with those treated with control ointment (8.4%) (P = .244). Subset analysis of flaps as a group and grafts as a group were not meaningful because the complication rates were so low.There is no survival increase of flaps and grafts treated with a single application of nitroglycerin ointment. |
| Databáze: | OpenAIRE |
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