Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery
| Autor: | Felipe Pereira Gomes, Janaíne Micheli Chassot, Cristiane de Bona da Silva, Luana Mota Ferreira, Letícia Cruz, Leandro Tasso |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Dispersity Excipient lcsh:RS1-441 Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Nanocapsules Pullulan lcsh:Pharmacy and materia medica chemistry.chemical_compound medicine Zeta potential General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification Nanocapsules/diffusion technique Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Pullulan/polymeric stabilizer chemistry Chemical engineering Drug delivery Biocompatible polymers Beclomethasone dipropionate/nanocapsules Nanocarriers 0210 nano-technology medicine.drug |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences; Vol. 52 No. 4 (2016); 735-740 Brazilian Journal of Pharmaceutical Sciences; Vol. 52 Núm. 4 (2016); 735-740 Brazilian Journal of Pharmaceutical Sciences; v. 52 n. 4 (2016); 735-740 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP Brazilian Journal of Pharmaceutical Sciences, Vol 52, Iss 4, Pp 735-740 Brazilian Journal of Pharmaceutical Sciences, Volume: 52, Issue: 4, Pages: 735-740, Published: DEC 2016 |
| ISSN: | 2175-9790 1984-8250 |
| Popis: | Polymeric stabilizers have received attention in the preparation of nanostructured systems due to their ability to enhance formulation stability. Considering this, the objective of this work was to prepare poly(ε-caprolactone) nanocapsules using the pullulan as a polymeric stabilizer. The nanocapsules were prepared using the interfacial deposition method of preformed polymers and they were characterized in terms of pH, average diameter, polydispersity index, zeta potential, beclomethasone dipropionate content, encapsulation efficiency, photostability and drug release profiles. The formulations showed physicochemical characteristics consistent with nanocarriers for drug delivery such as: average diameter lower than 270 nm, polydispersity indexes lower than 0.2, negative zeta potential (-22.7 to -26.3 mV) and encapsulation efficiencies close to 100%. In addition, the nanocapsules were able to delay the beclomethasone dipropionate photodegradation under UVC radiation and by the dialysis bag diffusion technique, the nanocapsules were able to prolong the drug release. Thus, pullulan could be considered an interesting excipient to formulate polymeric nanocapsules. |
| Databáze: | OpenAIRE |
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