Cryopreserved amniotic membrane in the treatment of diabetic foot ulcers: a case series
| Autor: | Patricio J Alcaraz, Ma Dolores López Lucas, Francisco J. Nicolás, Cristina Fuente Mora, José M. Moraleda, Guadalupe Ruiz Merino, Carmen L. Insausti, Antonio Piñero, Mónica Rodríguez Valiente, Gregorio Castellanos, Miguel Blanquer, Sonia Almansa, Maria del Carmen Algueró, Ana M García-Hernández |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Nursing (miscellaneous) Adolescent Cryopreservation Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Amnion Prospective Studies 030212 general & internal medicine Aged Aged 80 and over Wound Healing business.industry Middle Aged Allografts Antimicrobial medicine.disease Diabetic foot Diabetic Foot Surgery Treatment Outcome Diabetic foot ulcer Spain Female Fundamentals and skills business Wound healing |
| Zdroj: | Journal of Wound Care. 27:806-815 |
| ISSN: | 2052-2916 0969-0700 |
| DOI: | 10.12968/jowc.2018.27.12.806 |
| Popis: | Objective: The amniotic membrane (AM) is a tissue with low immunogenity and high therapeutic potential due to its anti-inflammatory, anti-fibrotic and antimicrobial effects. This paper describes the use of cryopreserved amniotic membrane allografts to treat diabetic foot ulcers (DFUs) in patients with diabetes. Method: In this case series, AM was processed to obtain a final medicinal product: cryopreserved amniotic membrane. cryopreserved AM was applied every 7–10 days until total epithelialisation of the DFUs. Results: A total of 14 patients with DFUs (median size: 12.30cm, (range: 0.52–42.5cm2) were treated and followed up until complete closure (median time: 20 weeks, range: 7–56 weeks). Patients received 4–40 AM applications. All patients in this study achieved complete epithelialisation of the wound. No adverse events were observed. Conclusion: AM is a feasible and safe treatment in complex DFUs. Furthermore, the treatment is successful in achieving epithelialisation of long-evolution, unhealed wounds resistant to conventional therapies. |
| Databáze: | OpenAIRE |
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