Effects of Paroxetine on Cutaneous Wound Healing in Healthy and Diabetic Rats
| Autor: | Esra Pancar Yuksel, Fatma Aydin, Nilgün Şentürk, Fatih Ilkaya, Levent Yildiz, Tayyar Cantürk, Ahmet Yaşar Turanli, Hilal Denizli |
|---|---|
| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Neutrophils medicine.medical_treatment Dermatology Gastroenterology Diabetes Mellitus Experimental Rats Sprague-Dawley Random Allocation fibroblasts Diabetes mellitus Internal medicine Inflammatory cell Animals Medicine Fibroblast Saline Advanced and Specialized Nursing Wound Healing business.industry epithelialization Fibroblasts medicine.disease Paroxetine Rats medicine.anatomical_structure Wounds and Injuries Cutaneous wound business Wound healing cutaneous wounds Injections Intraperitoneal paroxetine medicine.drug Blood vessel |
| Zdroj: | Advances in Skin & Wound Care. 27:216-221 |
| ISSN: | 1527-7941 |
| DOI: | 10.1097/01.asw.0000445920.14039.64 |
| Popis: | WOS: 000336728900005 PubMed: 24732125 OBJECTIVE: The aim of this study was to evaluate the histologic effects of acute paroxetine administration on wound healing in healthy and streptozotocin-induced diabetic rats. DESIGN: This study has a randomized controlled experimental design. SETTING: Healthy (n = 32) and diabetic (n = 32) rats were further divided into 2 groups of saline or paroxetine administration. PARTICIPANTS: Sixty-four male Sprague-Dawley rats were used in this study. INTERVENTIONS: Paroxetine was injected intraperitoneally every day. Full-thickness excision wounds were created with a 4-mm dermal punch on the back of all rats. The healing wound area was removed with a 6-mm dermal punch at postwounding days 1, 3, 7, and 14. MAIN OUTCOME MEASURES: Polymorphonuclear leukocyte, mononuclear inflammatory cell, fibroblast, and blood vessel counts and epithelialization were evaluated under light microscope. MAIN RESULTS: There was no statistically significant difference observed in the polymorphonuclear leukocyte, mononuclear inflammatory cell, and blood vessel counts in the healthy and diabetic rats with and without paroxetine administration. The number of fibroblasts was significantly higher at postwounding day 14 of the paroxetine-administered healthy rats compared with the saline-administered healthy rats (P = .04). However, the number of fibroblasts did not show any difference by paroxetine administration in the diabetic rats. There was no statistically significant difference in epithelialization regarding all the postwounding days, but complete epithelialization was observed in all rats on postwounding day 14 in the healthy and paroxetine-administered group. CONCLUSION: Short-term paroxetine administration may enhance cutaneous wound healing by increasing the number of fibroblasts and causing better epithelialization over time in healthy rats but not in diabetic rats. Ondokuz Mayis UniversityOndokuz Mayis University [PYO.TIP.1901.12.020] This study was supported by project number PYO.TIP.1901.12.020 by Ondokuz Mayis University. Submitted April 1, 2013; accepted in revised form August 16, 2013. |
| Databáze: | OpenAIRE |
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